Lab Sciences
Top stories summarized by our editors
9/25/2018

Patients with atrial fibrillation who take clot-preventing pills daily experienced fewer strokes, based on data published in the journal Stroke from a study that compared a group taking Coumadin, or warfarin, and those taking newer oral anticoagulants. The annual stroke rate for the group taking warfarin was 2.1 for every 100,000 patients compared with the annual stroke rate of 1.17 for every 100,000 patients among those taking NOACs.

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Reuters
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warfarin
9/25/2018

A survey about HIV-prevention methods among men who have sex with men found a 4.1% rate of usage of pre-exposure prophylaxis but a 68% positive view of the treatment.

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MD Magazine online
9/25/2018

Atomo Diagnostics and Mylan Pharmaceuticals have signed a global marketing agreement to commercialize the former's CE-marked HIV self-tests in over 100 nations in Asia, Africa, Latin America, the Middle East and the former Soviet Union. A global launch for the Mylan HIV Self-Test is slated for early next year.

9/25/2018

A third patient has received AMT-061, uniQure's investigative gene therapy for hemophilia B, in a Phase IIb clinical trial. Dose confirmation and topline data are expected this year.

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Seeking Alpha
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uniQure
9/25/2018

There are a variety of pitfalls in using indirect ion-selective electrode values and the level of proteins, albumin or triacylglycerols to calculate sodium concentration in patients with hyperproteinemia or hyperlipidemia. Beyond certain protein and lipid concentration cutoffs, labs should report serum electrolyte levels through direct ISE only, according to this piece, and they should talk to clinicians about the potential for discrepancies between these two technologies.

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hyperlipidemia
9/24/2018

Efforts to curb the spread of the Ebola virus in and near the town of Beni in the Democratic Republic of Congo were interrupted Saturday by a rebel attack in the area that killed at least four soldiers and 14 civilians. Local authorities reported the death due to the virus of a Congolese woman near the Ugandan border after she had declined vaccination and left Beni.

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Reuters, ABC News
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Ebola
9/24/2018

People who contracted HIV and hepatitis through blood products in the UK in the 1970s and 1980s testified at the beginning of an inquiry into the National Health Service and its practices at the time. An estimated 5,000 UK residents with bleeding conditions including hemophilia contracted the viruses through injections of pooled and concentrated blood products.

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BBC
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HIV, National Health Service
9/24/2018

Two studies provide new information on a rare but significant group of HIV patients known as post-treatment controllers who have maintained viral control despite cessation of antiretroviral therapy. Findings from the first study established the correlation between PTC status and early treatment and were published in The Journal of Infectious Diseases, while results from the second study, which dealt with the biological mechanisms in PTCs, were reported in The Journal of Clinical Investigation.

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MD Magazine online
9/24/2018

Jivi, or damoctocog alfa pegol/BAY94-9027, a product of Bayer, has received approval from Japanese regulators for the prevention of bleeds in patients with hemophilia A ages 12 and older. Jivi is now under regulatory review in Europe.

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PMLive (UK)
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Bayer, Jivi
9/21/2018

A study of blood serum levels of chemokines among women with and without sickle cell disease found that the protein IP-10 may be an indicator of inflammation for women with sickle cell disease during pregnancy. From that group, blood samples were collected in the second trimester of pregnancy and at least a month after transfusion, according to the study in the journal Cytokine.